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5-Amino-1MQ is a small-molecule quinolinium compound — not a peptide — that selectively inhibits nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme involved in the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor

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We anticipate that more efficacious intervention strategies that protect neural cells against METH-induced neurotoxic consequences may be implemented in the future